Fundamental acquisition of the cardinal attributes of a neoplastic lesion might concern the evolving transformation quantitatively of qualitative systems of a sequentially progressive nature. The highly increased proliferative rates of activity of neoplastic tissues would in various ways constitute an integrally sequential series of pathways also actively incorporating the local infiltration of tissues and the complex interplay of involvement constituting metastatic tumor spread in the body. It is indeed in terms of an essential sequential progressiveness that is primarily a biologic attribute of cells that is also potentially an axis of involvement in terms of a neoplastic transformation that one might realize multiple potential pathways of evolution even as an integral carcinogenetic event. It is with regard to a strict definition of carcinogenetic transformation that one might conceptualize a cell proliferative activity as part of an integral sequentiality leading to activated progressiveness of cell biologic attributes. Such sequential progressiveness of cell biology would perhaps be strictly characterized as a true form of pathobiologic transformation of neoplastic type simply in terms of induced quantitative variability influencing paradoxically qualitative determinants of cellular activity. In such terms, malignant cellular transformation would specifically arise as an integral system of pathologic evolution inherent to distinct biologic progressiveness of various cellular attributes referable to metabolic, proliferative, membrane physiologic, oxidative and genetic type as quantitatively variable but sequentially progressive even as transformational events.