International Journal of Molecular Medicine and Advance Sciences
2011,
Volume 7,
Issue 3
: 16-18
doi: ijmmas.2011.16.18
Research Article
4-Methylphenylsemicarbazone Derivatives Inhibits Cow Milk Induced Pyrexia in Rabbits
Abstract
A series of 4-methylphenylsemicarbazone was synthesized and investigated for their antipyretic activity using boiled cow milk induced pyrexia in rabbits. It was observed that the compound 4MS-8 exhibited maximum protection against pyrexia. Hydroxy substitution in aldehydic and acetophenic moiety of 4-methylphenylsemicarbazone derivatives significantly increased antipyretic activity.
Keywords
Pyrexia
Cow milk
Antipyretic
4-methylphenylsemicarbazone
Derivatives
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